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TickerAZN
SectorDrug Manufacturers - General
Mkt cap$282.1B
EV / EBITDA15.0×
PostureUnder Pressure
Composite53/100
LensTarget-side
SE-Cluster Research·Issuer Brief·Q2 2026CIK 901832

Astrazeneca PLC

AZNUNDER PRESSUREQUIET

Astrazeneca PLC reads as Under Pressure (composite 53/100); pressure / disclosure signals dominate the posture this cycle · primary market Healthcare, ranked #6 on disclosed spend.

Lens

Disclosed M&A capital (2023–2025)

$19M

−99%

vs $41.1B in 2020–2022

Disclosed transactions

N/A

−99%

2/3 active fiscal years in window

Buyer archetype

Transformational Buyer

Episodic but very large disclosed transactions drive the profile.

Composite score

53

/100

Under Pressure dominates · Quiet

Financial snapshot
Revenue$60.4B
EBITDA$20.5B
Enterprise value$308.4B
EV / Revenue5.1×
EV / EBITDA15.0×
P/EN/A
Cash$5.7B
Total debt$29.6B
as of 2026-05-10
§ I·SE-Cluster Issuer Brief

Behavioral posture, nine reads.

Each index scores the issuer 0–100 against an EDGAR-anchored definition. Scores ≥ threshold elevate the issuer into the index's constituent set; the dominant index drives the masthead label.

Active Acquirer

51/100

Companies actively deploying disclosed capital into M&A

  • $41.1B disclosed buyer spend

Buyer Cadence

0/100

Buyer-side companies with recent filing activity

Target Probability

34/100

Issuers showing target-side patterns from filings

  • Control-process language
  • 16 activism filings

Spin/Carve

0/100

Issuers showing spin-off, carve-out, or sum-of-parts posture

  • 16 activism filings

Pressure Watch

Dominant
53/100

Issuers facing activism, governance, or control pressure

  • 16 activism filings
  • Latest activism 2.5y ago; discounted
  • Shareholder pressure language
  • Control-process filings

Distress Watch

30/100

Issuers showing financial-distress filing patterns

  • Missing recent 10-Q
  • 16 activism filings

Restatement Risk

0/100

Issuers with accounting-integrity flags from filings

Capital Velocity

34/100

Issuers with the highest filing-activity intensity

  • 3 form types

Quiet Power

0/100

Large issuers with low signal volume and clean disclosure cadence

  • Enterprise value $308.4B
  • 4 active signals
§ II·SE-Cluster Issuer Brief

Capital cadence.

Ten-year disclosed M&A activity. Bars show spend ($MM); ticks show recorded transaction count. Disclosure tier annotated where v6 audited corpus carries an entry.

16
17
18
19
20
21
22
23
24
25

Disclosed spend $MM Disclosed transactions (right axis)Peak spend year: $41,058M · Peak count: 2

FYDisclosed buysDisclosed spendAvg ticketAudited tier
2025N/A$200KN/AN/A
2024N/A$18MN/AN/A
2023N/AN/AN/AN/A
2022N/A$27MN/AN/A
20212$41.1B$20.5BN/A
2020N/AN/AN/AN/A
§ V·SE-Cluster Issuer Brief

Market context.

Where this issuer sits inside its SE-Cluster rollup wedge, with disclosed-spend rank plus trading comparables against the public peer set.

Primary market

Healthcare

Market spend (2023–2025)
$195B
Market spend (2020–2022)
$253.6B
Recent vs prior
−23%
Issuer rank in market
#6 of 391
Share of market capital
4.6%

Valuation positioning

15.0×EV / EBITDA

AZN trades at a +2.1-turn premium to the Healthcare peer median of 12.9×.

EV / Revenue
5.1×
Net debt / EBITDA
1.2×
Peer median EV / EBITDA
12.9×

Trading comparables

FMP market data · 2026-05-10

CompanyEV / EBITDAEV / RevNet debt / EBITDARevenueM&A 2023–2025
23.4×6.7×3.1×$62.8B$18B
17.2×0.9×1.9×$449.7B$28.1B
Astrazeneca PLCAZN
15.0×5.1×1.2×$60.4B$19M
12.9×6.0×2.6×$37.2B$26.7B
11.7×0.5×2.5×$200.4B$6.4B
9.3×1.9×2.8×$76.4B$1.3B

Trading multiples from FMP market data; disclosed M&A spend from the SE-Cluster EDGAR 10-K corpus. Peer set = top disclosed buyers in Healthcare. Bars scaled to the highest EV/EBITDA in the set.

§ VI·SE-Cluster Issuer Brief

Buyer landscape.

Public buyers whose stated archetypes, target categories, and recent cadence align with this issuer as a plausible acquisition target. Scores cross EDGAR signal and disclosure overlap.

Likely buyers

No public buyers surface as a strong target-side fit on current signal.

Likely sellers / divestiture partners

No reciprocal divestiture / strategic-alternatives matches identified.

§ VII·SE-Cluster Issuer Brief

Filing activity & signal stream.

Filing cadence and event-driven signals visible on EDGAR. The signal stream below is curated from restatement / spin-carve / activism categories, providing context for any near-term call.

Filing cadence

  • 10-K (annual)252026-02-24
  • 10-Q (quarterly)0N/A
  • 8-K (event)0N/A
  • Proxy / DEF 14A12024-03-19
  • Activism (13D / DFAN / PREC)162023-11-16

Signals on file

  • elevated

    Activism on file

    2023-11-16

    16 activist filings on file (13D, DFAN14A, PREC14A series).

  • info

    Signal

    Serial acquisition history

  • info

    Signal

    Recent transaction activity

  • info

    Signal

    Shareholder pressure

§ VIII·SE-Cluster Issuer Brief

Audited corpus.

No audited record on file for this CIK in the current v6 corpus.

This issuer has not been extracted into the v6 audited acquirer corpus yet. The brief above pulls from ranking-level aggregates and issuer-index signal only.

Astrazeneca PLC: Issuer Brief | SE-Cluster