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TickerINSM
SectorBiotechnology
Mkt cap$22B
EV / EBITDAN/A
PostureHigh Velocity
Composite70/100
LensBuyer-side
SE-Cluster Research·Issuer Brief·Q2 2026CIK 1104506

Insmed Inc.

INSMHIGH VELOCITYFILING INTENSITY

Insmed Inc. reads as an High Velocity (composite 70/100); Consistent Strategic Buyer deploying $195M across 3 disclosed transactions, running flat vs the prior cycle · primary market Healthcare.

Lens

Disclosed M&A capital (2023–2025)

$195M

+13%

vs $172M in 2020–2022

Disclosed transactions

3

−40%

3/3 active fiscal years in window

Buyer archetype

Consistent Strategic Buyer

Meaningful spend appears across repeat years.

Composite score

70

/100

High Velocity dominates · Filing Intensity

Financial snapshot
Revenue$820M
EBITDAN/A
Enterprise value$21.4B
EV / Revenue26.1×
EV / EBITDAN/A
P/EN/A
Cash$582M
Total debt$547M
as of 2026-05-10
§ I·SE-Cluster Issuer Brief

Behavioral posture, nine reads.

Each index scores the issuer 0–100 against an EDGAR-anchored definition. Scores ≥ threshold elevate the issuer into the index's constituent set; the dominant index drives the masthead label.

Active Acquirer

35/100

Companies actively deploying disclosed capital into M&A

  • $463M disclosed buyer spend

Buyer Cadence

38/100

Buyer-side companies with recent filing activity

  • Filed within 33d
  • 358 8-Ks

Target Probability

4/100

Issuers showing target-side patterns from filings

Spin/Carve

0/100

Issuers showing spin-off, carve-out, or sum-of-parts posture

Pressure Watch

14/100

Issuers facing activism, governance, or control pressure

Distress Watch

0/100

Issuers showing financial-distress filing patterns

Restatement Risk

0/100

Issuers with accounting-integrity flags from filings

Capital Velocity

Dominant
70/100

Issuers with the highest filing-activity intensity

  • 358 8-Ks
  • 4 form types

Quiet Power

49/100

Large issuers with low signal volume and clean disclosure cadence

  • Enterprise value $21.4B
  • 10-Q 33d ago
  • 2 active signals
§ II·SE-Cluster Issuer Brief

Capital cadence.

Ten-year disclosed M&A activity. Bars show spend ($MM); ticks show recorded transaction count. Disclosure tier annotated where v6 audited corpus carries an entry.

16
17
18
19
20
21
22
23
24
25

Disclosed spend $MM Disclosed transactions (right axis)Peak spend year: $166M · Peak count: 3

FYDisclosed buysDisclosed spendAvg ticketAudited tier
20251$40M$40MN/A
2024N/A$72MN/AN/A
20232$83M$41MN/A
20222$166M$83MN/A
20213$7M$2MN/A
2020N/AN/AN/AN/A
§ III·SE-Cluster Issuer Brief

Strategy posture.

The buyer's playbook in terms of strategic archetype: what each disclosed move says about how they're deploying capital.

Archetype mix

  • Technology Acquisition
    100%

Strategy keywords

Terms recurring across recent 10-K acquisition disclosures.

  • technology_acquisition
§ IV·SE-Cluster Issuer Brief

Filing language.

Direct excerpts from acquisition disclosures and strategy sections: the verbs the buyer chose, in the filings they signed.

In August 2021, we acquired Motus Biosciences, Inc. (Motus) and AlgaeneX, Inc. (AlgaeneX), preclinical stage companies engaged in the research, development and manufacturing of gene therapies for rare genetic disorders.

10-KFY2021

In March 2021, we acquired a proprietary protein deimmunization platform, called Deimmunized by Design

10-KFY2021

In December 2025, we acquired global rights to OpSCF (renamed INS1148) from Opsidio LLC (Opsidio).

10-KFY2025

In December 2025, we acquired INS1148, a Phase 2-ready monoclonal antibody targeting SCF248.

10-KFY2025
§ V·SE-Cluster Issuer Brief

Market context.

Where this issuer sits inside its SE-Cluster rollup wedge, with disclosed-spend rank plus trading comparables against the public peer set.

Primary market

Healthcare

Market spend (2023–2025)
$195B
Market spend (2020–2022)
$253.6B
Recent vs prior
−23%
Issuer rank in market
N/A
Share of market capital
0.0%

Valuation positioning

N/AEV / EBITDA

INSM trades at a -31.7-turn discount to the Healthcare peer median of 12.9×.

EV / Revenue
26.1×
Net debt / EBITDA
N/A
Peer median EV / EBITDA
12.9×

Trading comparables

FMP market data · 2026-05-10

CompanyEV / EBITDAEV / RevNet debt / EBITDARevenueM&A 2023–2025
23.4×6.7×3.1×$62.8B$18B
17.2×0.9×1.9×$449.7B$28.1B
12.9×6.0×2.6×$37.2B$26.7B
11.7×0.5×2.5×$200.4B$6.4B
9.3×1.9×2.8×$76.4B$1.3B

Trading multiples from FMP market data; disclosed M&A spend from the SE-Cluster EDGAR 10-K corpus. Peer set = top disclosed buyers in Healthcare. Bars scaled to the highest EV/EBITDA in the set.

§ VI·SE-Cluster Issuer Brief

Target landscape.

Public-issuer targets that fit this buyer's archetype and target categories from filing-derived signal. Scores reflect cross-signal fit; reasons cite the EDGAR-anchored facts that drove the match.

No qualifying public-issuer targets surfaced from the current signal mix.

Stated target categories

No target categories enumerated in the audited corpus for this issuer.

§ VII·SE-Cluster Issuer Brief

Filing activity & signal stream.

Filing cadence and event-driven signals visible on EDGAR. The signal stream below is curated from restatement / spin-carve / activism categories, providing context for any near-term call.

Filing cadence

  • 10-K (annual)362026-02-19
  • 10-Q (quarterly)842026-05-07
  • 8-K (event)3582026-05-07
  • Proxy / DEF 14A452026-04-01
  • Activism (13D / DFAN / PREC)0N/A

Signals on file

  • info

    Signal

    Serial acquisition history

  • info

    Signal

    10-K strategy themes

§ VIII·SE-Cluster Issuer Brief

Audited corpus.

No audited record on file for this CIK in the current v6 corpus.

This issuer has not been extracted into the v6 audited acquirer corpus yet. The brief above pulls from ranking-level aggregates and issuer-index signal only.

Insmed Inc.: Issuer Brief | SE-Cluster