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TickerNTRA
SectorMedical - Diagnostics & Research
Mkt cap$27.5B
EV / EBITDAN/A
PostureHigh Velocity
Composite70/100
LensTarget-side
SE-Cluster Research·Issuer Brief·Q2 2026CIK 1604821

Natera, Inc.

NTRAHIGH VELOCITYFILING INTENSITY

Natera, Inc. reads as High Velocity (composite 70/100); pressure / disclosure signals dominate the posture this cycle · primary market Life Sciences.

Lens

Disclosed M&A capital (2023–2025)

$16M

new

vs N/A in 2020–2022

Disclosed transactions

1

new

1/3 active fiscal years in window

Buyer archetype

Selective Buyer

Acquisition use is visible but targeted.

Composite score

70

/100

High Velocity dominates · Filing Intensity

Financial snapshot
Revenue$2.5B
EBITDAN/A
Enterprise value$26.7B
EV / Revenue10.7×
EV / EBITDAN/A
P/EN/A
Cash$1.1B
Total debt$80M
as of 2026-05-10
§ I·SE-Cluster Issuer Brief

Behavioral posture, nine reads.

Each index scores the issuer 0–100 against an EDGAR-anchored definition. Scores ≥ threshold elevate the issuer into the index's constituent set; the dominant index drives the masthead label.

Active Acquirer

15/100

Companies actively deploying disclosed capital into M&A

  • $70M disclosed buyer spend

Buyer Cadence

13/100

Buyer-side companies with recent filing activity

  • Filed within 32d
  • 106 8-Ks

Target Probability

16/100

Issuers showing target-side patterns from filings

  • 3 activism filings

Spin/Carve

0/100

Issuers showing spin-off, carve-out, or sum-of-parts posture

  • 3 activism filings

Pressure Watch

16/100

Issuers facing activism, governance, or control pressure

  • 3 activism filings
  • Latest activism 6.3y ago; heavily discounted

Distress Watch

14/100

Issuers showing financial-distress filing patterns

  • 3 activism filings

Restatement Risk

0/100

Issuers with accounting-integrity flags from filings

Capital Velocity

Dominant
70/100

Issuers with the highest filing-activity intensity

  • 106 8-Ks
  • 5 form types

Quiet Power

0/100

Large issuers with low signal volume and clean disclosure cadence

  • Enterprise value $26.7B
  • 10-Q 32d ago
  • 2 active signals
§ II·SE-Cluster Issuer Brief

Capital cadence.

Ten-year disclosed M&A activity. Bars show spend ($MM); ticks show recorded transaction count. Disclosure tier annotated where v6 audited corpus carries an entry.

16
17
18
19
20
21
22
23
24
25

Disclosed spend $MM Disclosed transactions (right axis)Peak spend year: $54M · Peak count: 1

FYDisclosed buysDisclosed spendAvg ticketAudited tier
20251$16M$16MN/A
2024N/AN/AN/AN/A
2023N/AN/AN/AN/A
2022N/AN/AN/AN/A
2021N/AN/AN/AN/A
2020N/AN/AN/AN/A
§ III·SE-Cluster Issuer Brief

Strategy posture.

The buyer's playbook in terms of strategic archetype: what each disclosed move says about how they're deploying capital.

Archetype mix

  • Talent Acquisition
    33%
  • Platform
    33%
  • Technology Acquisition
    33%

Strategy keywords

Terms recurring across recent 10-K acquisition disclosures.

  • talent_acquisition
  • platform
  • technology_acquisition
§ IV·SE-Cluster Issuer Brief

Filing language.

Direct excerpts from acquisition disclosures and strategy sections: the verbs the buyer chose, in the filings they signed.

In 2024, more than 92% of employees participated in our employee engagement survey, the results of which indicated an overall 84% engagement score, and that 91% of employees are proud to work at Natera (a 7% increase from 2023), and 80% would recommend Natera as a great place to work.

10-KFY2024

The acquisition was completed primarily to expand Natera’s intellectual property portfolio for tumor-informed and personalized MRD products including in phased variants and to build on Foresight’s clinical research momentum in B-cell lymphomas.

10-KFY2025

In addition to our compensation programs, we are highly focused on talent acquisition, retention and development.

10-KFY2022

We operate in an industry in which competition for highly qualified personnel is intense.

10-KFY2022
§ V·SE-Cluster Issuer Brief

Market context.

Where this issuer sits inside its SE-Cluster rollup wedge, with disclosed-spend rank plus trading comparables against the public peer set.

Primary market

Life Sciences

Market spend (2023–2025)
$68.3B
Market spend (2020–2022)
$107.5B
Recent vs prior
−36%
Issuer rank in market
N/A
Share of market capital
0.0%

Valuation positioning

N/AEV / EBITDA

NTRA trades at a -106.5-turn discount to the Life Sciences peer median of 16.1×.

EV / Revenue
10.7×
Net debt / EBITDA
N/A
Peer median EV / EBITDA
16.1×

Trading comparables

FMP market data · 2026-05-10

CompanyEV / EBITDAEV / RevNet debt / EBITDARevenueM&A 2023–2025
19.1×4.7×-0.0×$45.2B$10.8B
18.8×4.3×-0.3×$20.6B$8B
13.3×3.5×-0.1×$35.5B$2.2B
13.1×1.9×-0.2×$14.1B$2.1B

Trading multiples from FMP market data; disclosed M&A spend from the SE-Cluster EDGAR 10-K corpus. Peer set = top disclosed buyers in Life Sciences. Bars scaled to the highest EV/EBITDA in the set.

§ VI·SE-Cluster Issuer Brief

Buyer landscape.

Public buyers whose stated archetypes, target categories, and recent cadence align with this issuer as a plausible acquisition target. Scores cross EDGAR signal and disclosure overlap.

Likely buyers

No public buyers surface as a strong target-side fit on current signal.

Likely sellers / divestiture partners

No reciprocal divestiture / strategic-alternatives matches identified.

§ VII·SE-Cluster Issuer Brief

Filing activity & signal stream.

Filing cadence and event-driven signals visible on EDGAR. The signal stream below is curated from restatement / spin-carve / activism categories, providing context for any near-term call.

Filing cadence

  • 10-K (annual)112026-02-27
  • 10-Q (quarterly)352026-05-08
  • 8-K (event)1062026-05-07
  • Proxy / DEF 14A232026-04-23
  • Activism (13D / DFAN / PREC)32020-02-13

Signals on file

  • elevated

    Activism on file

    2020-02-13

    3 activist filings on file (13D, DFAN14A, PREC14A series).

  • info

    Signal

    Serial acquisition history

  • info

    Signal

    10-K strategy themes

§ VIII·SE-Cluster Issuer Brief

Audited corpus.

No audited record on file for this CIK in the current v6 corpus.

This issuer has not been extracted into the v6 audited acquirer corpus yet. The brief above pulls from ranking-level aggregates and issuer-index signal only.

Natera, Inc.: Issuer Brief | SE-Cluster